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KMID : 0360319930250060956
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Journal of Korean Cancer Research Association
1993 Volume.25 No. 6 p.956 ~ p.965
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Clinical Efficacy of Thymomodulin on Neutropenia Induced by Chemotherapy in the Patients with Gynecologic Cancer
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김병기
고창원/감종혁/송용상/강순범/이효표
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Abstract
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Thymomodulin(thymus extract, Leucon(r)) has been shown to be effective in accelerating the recovery of neutropenia following a variety of chemotherapeutic regimens. In this study we evaluated the efficacy and safety of Thymomodulin in the
patients
with
neutropenia before and/or after chemotherapy for gynecological cancers. Forty patients(cervical cancer, 29; ovarian cancer, 20) who were undergoing treatment with cytotoxic chemotherapy were selected and divided into two groups according to the
number
of leukocyte before chemotherapy. Leukocyte count was normal or higher in group I(20), and already neutropenic in group II(20) before chemotherapy.
Thymomodulin(15 ml/day) was administered to the 10 patients in each group for 15 days from the first day its effects were compared to that of placebo in 10 control patients in each group. There was no statistically significant difference in the
nadir of
the neutropenia after chemotherapy between Thymomodulin-treated and control patients in both groups. But duration of neutropenia and recovery from it were slightly shortened in Thymomodulin-treated patients in both group. The incidence of febrile
neutropenia was not lower in the Thymomodulin-treated patients than in the control patients. No remarkable adverse effect of the Thymomodulin administration was observed. In conclusion, Thymomodulin may be useful in accelerating the recovery of
neutropenia induced by cytotoxic chemotherapy in patients with gynecological cancer.
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KEYWORD
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